| 0 | - | cover | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Fig [Bethany Keele]; House of Mystery |
| 1 | House of Mystery #31 | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Fig [Bethany Keele] |
| 2 | Conception, Part 1 of 5: Come On | comic story | 16 | script: Matthew Sturges; pencils: Werther Dell'Edera; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Fig [Bethany Keele]; Ann Preston [as Ann Foley]; Cain; Cress [Cressida]; Genevieve Montaigne; Jordan Mayer; Lotus Blossom Mackenzie (first appearance); Poet [Eduard St. Germaine]; Tursig; Harry Bailey; Strawberry [William Keele]; Peter Keele; Grandpa Keele; House of Mystery; Pair of the Conception |
| 3 | The Mystery of the Missing Ghost | comic story | 6 | script: Penelope Klein; pencils: Marley Zarcone; inks: Marley Zarcone; colors: Marley Zarcone; letters: Todd Klein | Fig Keele [Bethany Keele]; Mikey Miller; Rowena; Butch McGruder |
| 4 | House of Mystery #32 | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Fig [Bethany Keele]; House of Mystery |
| 5 | Conception, Part 2 of 5: New Choices | comic story | 15 | script: Matthew Sturges; pencils: Werther Dell'Edera; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Fig [Bethany Keele]; Abel; Ann Preston; Cain; Cress [Cressida]; Genevieve Montaigne; Jordan Mayer; Lotus Blossom Mackenzie; Poet [Eduard St. Germaine]; Tursig; Harry Bailey; Strawberry [William Keele]; Peter Keele; Grandpa Keele; Mrs. Keele; House of Mystery; House of Secrets |
| 6 | Murder Most Foul! | comic story | 7 | script: Matthew Sturges; pencils: Enrique Breccia; inks: Enrique Breccia; colors: Lee Loughridge; letters: Todd Klein | Abel; Ann Preston; Cress [Cressida; also as Annadora-Bella]; Genevieve Montaigne [also as Lavina]; Jordan Mayer [also as Lord Snufflebun]; Tursig [also as Reginald Carstarphson] |
| 7 | House of Mystery #33 | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Fig [Bethany Keele]; House of Mystery |
| 8 | Conception, Part 3 of 5: Exceptional Problems | comic story | 10 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Fig [Bethany Keele]; Cain; House of Mystery; Carla (flashback); Jim (flashback); Ming (flashback); Donna (flashback); Pair of the Conception |
| 9 | Great Artists Steal | comic story | 10 | script: Matthew Sturges; pencils: David Lloyd; inks: David Lloyd; colors: David Lloyd; letters: Todd Klein | Sean Leeds; Tom (death); Mr. Bachman (death) |
| 10 | House of Mystery #34 | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Fig [Bethany Keele]; Cain; House of Mystery; Pair of the Conception |
| 11 | Conception, Part 4 of 5: Two Individuals | comic story | 14 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Fig [Bethany Keele]; Cain; House of Mystery; Administrator Ceorel; Pair of the Conception; Harry Bailey; Strawberry [William Keele]; Peter Keele; Grandpa Keele; Abel; Algernon Wells; Ann Preston; Jordan Mayer; Lotus Blossom Mackenzie; Poet [Eduard St. Germaine]; House of Secrets |
| 12 | Bloodsucker | comic story | 6 | script: Matthew Sturges; pencils: Ulises Fariñas; inks: Ulises Fariñas; colors: Brandon Graham; letters: Todd Klein | Bloodsucker [John Smith] (a vampire) |
| 13 | House of Mystery #35 | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Fig [Bethany Keele]; Harry Bailey; House of Mystery |
| 14 | Conception, Part 5 of 5: Over Now | comic story | 14 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Fig [Bethany Keele]; Cain; House of Mystery; The Conception; Harry Bailey; Strawberry [William Keele]; Peter Keele; Grandpa Keele; Abel; Algernon Wells; Ann Preston; Byzantium Mack; Cress [Cressida]; Genevieve Montaigne; Jordan Mayer; Lotus Blossom Mackenzie; Poet [Eduard St. Germaine]; Tursig; Hous |
| 15 | Necessary Evil | comic story | 6 | script: Matthew Sturges; pencils: Gene Ha; inks: Gene Ha; colors: Trish Mulvihill; letters: Todd Klein | Luke; Brendan; Allen; Trish |
| 16 | House of Mystery Halloween Annual #2 | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Cain; Bobby; Donald the Kid; Long John Tuchman; Twinkie |
| 17 | - | comic story | 10 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Abel; Cain; Fig [Bethany Keele]; Goldie; Ann Preston; Cress [Cressida]; Jordan Mayer; Tursig; House of Mystery; Madame Scarpignato; Bobby (first appearance); Donald the Kid (first appearance); Long John Tuchman (first appearance); Twinkie (first appearance) |
| 18 | - | comic story | 7 | script: Matt Wagner; pencils: Brandon Graham; inks: Brandon Graham; colors: Brandon Graham; letters: Jared K. Fletcher | Madame Xanadu [Nimue Inwudu]; Bobby; Donald the Kid; Long John Tuchman; Twinkie |
| 19 | Bonfire Night | comic story | 7 | script: Peter Milligan; pencils: Giuseppe Camuncoli, Stefano Landini; inks: Stefano Landini; colors: Trish Mulvihill; letters: Sal Cipriano | John Constantine; Bobby; Donald the Kid; Long John Tuchman; Twinkie; Katie Morgan; Mrs. Morgan; Mr. Watson (death); Gloria |
| 20 | Devil's Lake | comic story | 7 | script: Chris Roberson; pencils: Michael Allred; inks: Michael Allred; colors: Laura Allred; letters: Todd Klein | Gwen [as Gwendolyn]; Tricia; Darius; Bobby; Donald the Kid; Long John Tuchman; Twinkie |
| 21 | Infernal Bargains Just Say No! | comic story | 7 | script: Mike Carey; pencils: Peter Gross; inks: Peter Gross; colors: Daniel Vozzo; letters: Jared K. Fletcher | Lucifer; Gaudium; Spera; Bobby; Donald the Kid; Long John Tuchman; Twinkie |