| 0 | - | cover | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | House of Mystery |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Fig [Bethany Keele] |
| 2 | Thesis | recap | 2 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | |
| 3 | Desolation, Part 1 of 5: Dead End | comic story | 13 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Austin; Fig [Bethany Keele]; Gigi; Harry Bailey; Johnny; Lotus Blossom Mackenzie; Luke; Rod Cannon; House of Mystery |
| 4 | The Laws of Motion | comic story | 5 | script: Matthew Sturges; pencils: Darwyn Cooke; inks: Darwyn Cooke; colors: Dave Stewart; letters: Todd Klein | Rod Cannon; Linda |
| 5 | - | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | House of Mystery |
| 6 | Desolation, Part 2 of 5: Significant Others | comic story | 14 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Cain; The Conjurer [Earl Little]; Every1; Fig [Bethany Keele]; Gigi; Harry Bailey; Lotus Blossom Mackenzie; M. Emory; Rod Cannon; Simon; Tursig; House of Mystery |
| 7 | Death in the City | comic story | 6 | script: Matthew Sturges; pencils: Aaron Campbell; inks: Aaron Campbell; colors: Lee Loughridge; letters: Todd Klein | The Conjurer [Earl Little]; Maria Velerio; Luc Aiguillon (villain) |
| 8 | - | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Lotus Blossom Mackenzie; House of Mystery |
| 9 | Desolation, Part 3 of 5: Lost Advantages | comic story | 12 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Administrator Kynic; Byzantium Mack; Cain; The Conjurer [Earl Little]; Every1; Fig [Bethany Keele; also as The Conception]; Gigi; Harry Bailey; Strawberry [William Keele]; Peter Keele; Grandpa Keele; Lotus Blossom Mackenzie; M. Emory; House of Mystery |
| 10 | Communion | comic story | 8 | script: Matthew Sturges; pencils: David Lapham; inks: David Lapham; colors: Lee Loughridge; letters: Todd Klein | Byzantium Mack; Harry Bailey; Lotus Blossom Mackenzie |
| 11 | - | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Gigi [Goldie] |
| 12 | Desolation, Part 4 of 5: Teetering Infinities | comic story | 14 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Algernon Wells; Fig [Bethany Keele; also as The Conception]; Gigi [Goldie]; Harry Bailey; Strawberry [William Keele]; Lotus Blossom Mackenzie; Rod Cannon; Simon; Tursig; House of Mystery |
| 13 | A Story About a Gargoyle and a Girl | comic story | 6 | script: Matthew Sturges; pencils: Peter Snejbjerg; inks: Peter Snejbjerg; colors: Lee Loughridge; letters: Todd Klein | Abel; Algernon Wells; Fig [Bethany Keele; also as The Conception]; Gigi [Goldie] (origin); Harry Bailey; Jordan Meyer; Lotus Blossom Mackenzie; M. Emory; Strawberry [William Keele]; Tursig; House of Secrets |
| 14 | - | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Fig [Bethany Keele]; Lotus Blossom Mackenzie; Harry Bailey |
| 15 | Desolation, Part 5 of 5: Omneity's Negation | comic story | 20 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Byzantium Mack; Cain; The Conjurer [Earl Little]; Every1; Fig [Bethany Keele; also as The Conception]; Gigi [Goldie]; Harry Bailey; John Constantine (cameo flashback); Jordan Mayer; M. Emory; Strawberry [William Keele]; Lotus Blossom Mackenzie; Rod Cannon; Simon; House of Mystery |
| 16 | - | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | Fig [Bethany Keele] |
| 17 | Closing Time | comic story | 15 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Abel; Algernon Wells; Ann Preston; Byzantium Mack; Cain; The Conjurer [Earl Little]; Cress [Cressida]; Daphne; Fig [Bethany Keele]; Genevieve Montaigne; Gigi [Goldie]; Harry Bailey; Jordan Mayer; King Glob; Poet [Eduard St. Germaine]; Lotus Blossom Mackenzie; Rod Cannon; Mrs. Cannon; Simon; Tursig; |
| 18 | Mystery House | comic story | 5 | script: Lilah Sturges; pencils: Annie Wu; inks: Annie Wu; colors: Annie Wu; letters: Todd Klein | Blackberry; Borden; Larry; Lotus Blossom; Plum; Plum's father; T-Bone; The Thinking Man |
| 19 | - | cover reprint (on interior page) | 1 | pencils: Esao Andrews; inks: Esao Andrews; colors: Esao Andrews | House of Mystery |
| 20 | Three for the Road | comic story | 5 | script: Matthew Sturges; pencils: Luca Rossi; inks: José Marzán Jr.; colors: Lee Loughridge; letters: Todd Klein | Baron Qui; Kyung Soon Song; Dr. Cornelius; Dorcas; Alexandria; Glob; Tursig; Cain |
| 21 | A Birth of Spiders | comic story | 5 | script: Bill Willingham; pencils: Tony Akins; inks: Tony Akins; colors: Lee Loughridge; letters: Todd Klein | Baron Qui; Kyung Soon Song |
| 22 | Book Report | comic story | 5 | script: Steven T. Seagle; pencils: Teddy Kristiansen; inks: Teddy Kristiansen; colors: Teddy Kristiansen; letters: Todd Klein | Alexandria; Cain; Merv Pumpkinhead; House of Mystery |
| 23 | Room and Boredom (Slight Refrain) | comic story | 5 | script: Matthew Sturges; pencils: Inaki Miranda; inks: Inaki Miranda; colors: Eva de la Cruz; letters: Todd Klein | Dr. Cornelius; Miss Florabella; Abel; Byzantium Mack; Eduard the Great (first appearance); Gigi [Goldie]; Harry Bailey; Jordan Mayer; Lady Bethany; Lotus Blossom Mackenzie; Rod Cannon; Simon; House of Mystery; House of Secrets |