| 0 | - | cover | 1 | pencils: Clayton Crain; inks: Clayton Crain; colors: Clayton Crain | Andrew Bennett; Mary, Queen of Blood [Mary Seward] |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Ryan Sook; inks: Ryan Sook; colors: Ryan Sook | |
| 2 | Red Blood, Dark Magic | comic story | 20 | script: Peter Milligan; pencils: Admira Wijaya, Daniel Sampere; inks: Admira Wijaya, Daniel Sampere; colors: Admira Wijaya; letters: Rob Leigh | Laura; The Crystal One; Vampires (villains) |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Andrea Sorrentino; inks: Andrea Sorrentino | |
| 4 | Blame It on Cain | comic story | 20 | script: Joshua Hale Fialkov; pencils: Andrea Sorrentino; inks: Andrea Sorrentino; colors: Marcelo Maiolo; letters: Pat Brosseau | |
| 5 | - | cover reprint (on interior page) | 1 | pencils: Ryan Sook; inks: Ryan Sook; colors: Ryan Sook | |
| 6 | The Leaving | comic story | 20 | script: Peter Milligan; pencils: Daniel Sampere; inks: Daniel Sampere; colors: Admira Wijaya; letters: Dave Sharpe | |
| 7 | - | cover reprint (on interior page) | 1 | pencils: Andrea Sorrentino; inks: Andrea Sorrentino; colors: Marcelo Maiolo | |
| 8 | Cruel to Be Kind | comic story | 20 | script: Joshua Hale Fialkov; pencils: Andrea Sorrentino; inks: Andrea Sorrentino; colors: Marcelo Maiolo; letters: Pat Brosseau | |
| 9 | - | cover reprint (on interior page) | 1 | pencils: Andrea Sorrentino; inks: Andrea Sorrentino | Andrew Bennett |
| 10 | Hurry Down Doomsday (The Bugs Are Taking Over) | comic story | 20 | script: Joshua Hale Fialkov; pencils: Andrea Sorrentino; inks: Andrea Sorrentino; colors: Marcelo Maiolo; letters: Pat Brosseau | Andrew Bennett; John Troughton; Tig Rafelson; The Van Helsings; Mary, Queen of Blood [Mary Seward] (villain); Vampires (villains) |
| 11 | - | cover reprint (on interior page) | 1 | pencils: Clayton Crain; inks: Clayton Crain; colors: Clayton Crain | Andrew Bennett; The Van Helsings |
| 12 | Waiting for the End of the World | comic story | 20 | script: Joshua Hale Fialkov; pencils: Andrea Sorrentino; inks: Andrea Sorrentino; colors: Marcelo Maiolo; letters: Pat Brosseau | Andrew Bennett; John Troughton; Tig Rafelson; The Van Helsings; Mary, Queen of Blood [Mary Seward] |
| 13 | - | cover reprint (on interior page) | 1 | pencils: Clayton Crain; inks: Clayton Crain; colors: Clayton Crain | Andrew Bennett; Mary, Queen of Blood [Mary Seward] |
| 14 | The Drowning Man | comic story | 20 | script: Joshua Hale Fialkov; pencils: Andrea Sorrentino; inks: Andrea Sorrentino; colors: Marcelo Maiolo; letters: Pat Brosseau | Andrew Bennett; John Troughton; Tig Rafelson; The Van Helsings; Mary, Queen of Blood [Mary Seward] |
| 15 | - | cover reprint (on interior page) | 1 | pencils: Clayton Crain; inks: Clayton Crain; colors: Clayton Crain | Andrew Bennett; Mary, Queen of Blood [Mary Seward]; Stormwatch [Apollo; Jack Hawksmoor; Midnighter] |
| 16 | Disintegration | comic story | 20 | script: Joshua Hale Fialkov; pencils: Andrea Sorrentino; inks: Andrea Sorrentino; colors: Marcelo Maiolo; letters: Pat Brosseau | Andrew Bennett; John Troughton; Tig Rafelson; The Van Helsings; Mary, Queen of Blood [Mary Seward]; Stormwatch [Apollo; Engineer [Angie Spica]; Midnighter; Jack Hawksmoor] |
| 17 | Van Helsing Character Sketch by Andrea Sorrentino | illustration | 1 | pencils: Andrea Sorrentino; inks: Andrea Sorrentino; colors: Andrea Sorrentino | |
| 18 | Cain Character Sketch by Ryan Sook | illustration | 1 | script: Ryan Sook; pencils: Ryan Sook; inks: Ryan Sook; colors: Ryan Sook; letters: Ryan Sook | |
| 19 | Cain Character Sketch by Andrea Sorrentino | illustration | 1 | pencils: Andrea Sorrentino; inks: Andrea Sorrentino; colors: Andrea Sorrentino | |
| 20 | Andrew Bennett Character Sketches by Andrea Sorrentino | illustration | 2 | pencils: Andrea Sorrentino; inks: Andrea Sorrentino | |
| 21 | I, Vampire #7 Cover Sketches by Andrea Sorrentino | illustration | 3 | pencils: Andrea Sorrentino; inks: Andrea Sorrentino | |