| 0 | - | cover | 1 | pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | |
| 1 | Table of Contents | table of contents | 2 | letters: typeset | |
| 2 | Introduction | foreword, introduction, preface, afterword | 6 | script: Nick Meglin; colors: Marie Severin | |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | |
| 4 | MAD Mumblings | letters page | 1 | script: Harvey Kurtzman, William Gaines; pencils: Harvey Kurtzman; inks: Harvey Kurtzman | |
| 5 | Hoohah! | comic story | 8 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Galusha; Daphne; Melvin The Caretaker; two unnamed Silver Avengers kids |
| 6 | Blobs! | comic story | 7 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Melvin; Alfred |
| 7 | E.C. Fans! | promo (ad from the publisher) | 1 | colors: Marie Severin | |
| 8 | Enter Cosmo McMoon! | text story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | Captain O'Malley; Omar Kayak; Mrs. Kayak; Cosmo McMoon |
| 9 | Crow Vadis? | text story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | Tiberius O'Leary |
| 10 | Ganefs! | comic story | 6 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Bumble; Bumble's boss |
| 11 | Varmint! | comic story | 7 | script: Harvey Kurtzman; pencils: J. Severin; inks: J. Severin; colors: Marie Severin | Textron Quickdraw; Saddlesore; Kickiminabelly Kelly; Slippery Sam; The Pig-Faced Kid |
| 12 | Mad | cover reprint (on interior page) | 1 | pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin; letters: Ben Oda | Casey; Old Dame |
| 13 | E.C. Fans! | promo (ad from the publisher) | 1 | pencils: Al Feldstein; inks: Al Feldstein | |
| 14 | Hex! | comic story | 8 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Casey; Yeggi Bora; Leo; the Old Dame; Stan Musical; Preacher Rowboat; Eddy Stunky; Melvin Demoogio |
| 15 | Melvin! | comic story | 7 | script: Harvey Kurtzman; pencils: John Severin; inks: John Severin; colors: Marie Severin | Melvin of the Apes; Boy; Jane; Ookaballakonga tribe |
| 16 | E.C. Fans! | promo (ad from the publisher) | 1 | colors: Marie Severin | |
| 17 | Lady-in-Mascara | text story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | Monongahela Wheeler; Bablou O'Brien; Lady-in-Mascara; Max; Minx |
| 18 | Calling Cosmo McMoon! | text story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | Cosmo McMoon; F. M. Wavelength; Walla-Walla Bazinski; Croton-on-the-Hudson Bazinski; Baden-Baden Bazinski |
| 19 | Gookum! | comic story | 6 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Glarf Nerfnick; Glarf's grandfather; Melvin |
| 20 | Mole! | comic story | 7 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Melvin Mole |
| 21 | Vampire in the Cemetery | cover reprint (on interior page) | 1 | pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | |
| 22 | - | letters page | 1 | script: Harvey Kurtzman, William Gaines; pencils: Harvey Kurtzman; inks: Harvey Kurtzman | |
| 23 | Dragged Net! | comic story | 8 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Joe Friday; Ed Saturday; Mr. Glotz; The Chief |
| 24 | Sheik of Araby! | comic story | 7 | script: Harvey Kurtzman; pencils: John Severin; inks: John Severin; colors: Marie Severin | Roquefort; Camembert; Chantilly; Sergeant Guillotine; Goscinny; Frothingbash; Pastafazoo; Hossenpfeffer; Rasputin; Melvin; Melvin's wife Rosie |
| 25 | E.C. Fans! | promo (ad from the publisher) | 0.5 | pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | |
| 26 | Rookie Gladiator | text story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | |
| 27 | - | promo (ad from the publisher) | 0.5 | pencils: Don Cameron; inks: Don Cameron | |
| 28 | The Dandelion Caper | text story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | Cosmo McMoon; Malfeasance O'Malley; Morningside Mac Mixmaster; Truman Remote; Vino Muscatel; Marie Severin |
| 29 | V-Vampires! | comic story | 6 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Godiva; Godiva's kid brothers; Renfrew |
| 30 | Lone Stranger! | comic story | 7 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Lone Stranger; Golden; Pronto |
| 31 | Mad | cover reprint (on interior page) | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 32 | - | letters page | 1 | script: Harvey Kurtzman, William Gaines; pencils: Harvey Kurtzman; inks: Harvey Kurtzman | |
| 33 | Superduperman! | comic story | 8 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin; letters: Ben Oda | Superduperman [Clark Bent]; Lois Pain; Copy Boy; W. Twitchell; Captain Marbles [Billy Spafon] |
| 34 | Flob Was a Slob! | comic story | 7 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin; letters: Ben Oda | Ramona Snarfle; Sheldon Flob; Rackstraw Him |
| 35 | We at E.C. Are Proudest of Our Science-Fiction Magazines! | promo (ad from the publisher) | 0.5 | pencils: Al Williamson; inks: Al Feldstein; colors: Marie Severin | |
| 36 | The Parole | text story | 1 | script: Jerry DeFuccio; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | Tumblers Tympannus; Tiberious O'Leary |
| 37 | - | promo (ad from the publisher) | 0.5 | pencils: Don Cameron; inks: Don Cameron | |
| 38 | Let's Deplore Your Mind | text story | 1 | script: Jerry DeFuccio; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | Cosmo McMoon |
| 39 | Robin Hood! | comic story | 6 | script: Harvey Kurtzman; pencils: John Severin; inks: John Severin; colors: Marie Severin; letters: Ben Oda | Robin Hood; Big John; Sparkie; Alan Adaile; Friar Tuck; Little John; Happy; Sneezy; Sleepy; Doc; Dopey; Bashful; Grumpy; Maid Marion |
| 40 | Shadow! | comic story | 7 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin; letters: Ben Oda | Margo Pain; Lamont Shadowskeedeeboomboom |
| 41 | - | cover reprint (on interior page) | 1 | pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin; letters: Ben Oda | Kane Keen |
| 42 | The EC "Publisher of the Issue" | text article | 1 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | William M. Gaines [Melvin] |
| 43 | Outer Sanctum! | comic story | 8 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Ramon; The Professor; Heap |
| 44 | Black and Blue Hawks! | comic story | 7 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Saddlesore; Saurbratten; Robespierre; Boss Hawk; Yonny Yohnson; Chop Chop Chop; woman in red |
| 45 | We at E.C. Are Proudest of Our Science-Fiction Magazines | promo (ad from the publisher) | 1 | colors: Marie Severin | |
| 46 | Exam | text story | 1 | script: Jerry DeFuccio; pencils: John Severin; inks: John Severin; colors: Marie Severin | |
| 47 | MAD Mumblings | letters page | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | |
| 48 | Miltie of the Mounties! | comic story | 6 | script: Harvey Kurtzman; pencils: John Severin; inks: John Severin; colors: Marie Severin | Scott Yardland; Jackie; Herbie; Jerkie; Scoggins; Miltie; Nanuk The Canuk |
| 49 | Kane Keen! Private Eye | comic story | 7 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Kane Keen; Lassie Rover; Rollover Rover; Schlep; Mrs. Rover; laywer; police officer |
| 50 | - | cover reprint (on interior page) | 1 | pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 51 | If You Haven't Been Able to Find 'MAD' on Your Local Newsstand... | promo (ad from the publisher) | 1 | pencils: Jack Davis; inks: Jack Davis | |
| 52 | Teddy and the Pirates! | comic story | 8 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Teddy; Half-Shot; Pat O'Bryan; Burma Shave; Mr. Sandthirst; Connie; Big-Poop; The Dragging Lady; The Pirates |
| 53 | Melvin of the Apes! | comic story | 7 | script: Harvey Kurtzman; pencils: John Severin; inks: John Severin; colors: Marie Severin | Melvin of The Apes [Lord Melvin Greystroke]; Jane; Ookaballakonga tribe; Whitegreen Greystroke; Brown Greystroke; Veridian Greystroke; Magenta Greystroke; Duke Greystroke; Duchess Fushia Greystroke; |
| 54 | We At E.C. Are Proudest of Our Science-Fiction Magazines! | promo (ad from the publisher) | 1 | colors: Marie Severin | |
| 55 | Hevo the Great | text story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | Hevo Franklin; Red Haring |
| 56 | - | letters page | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | |
| 57 | Casey at the Bat! | comic story | 6 | script: Ernest Lawrence Thayer, Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Cooney; Burrows; Flynn; Blake; Casey; umpire |
| 58 | Ping Pong! | comic story | 7 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Cecil B. V. D. Mill; ship's captain; ship's crew; Mr. Mill's cameraman; Lana Lynn; Pong; Ookabolaponga tribe |