| 0 | - | cover | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | Shermlock Shomes; Dr. Whatsit |
| 1 | Table of Contents | table of contents | 2 | letters: typeset | |
| 2 | Introduction | foreword, introduction, preface, afterword | 5 | script: Frank Jacobs; colors: Marie Severin | |
| 3 | - | cover reprint (on interior page) | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | Shermlock Shomes; Dr. Whatsit |
| 4 | If You Haven't Been Able To Find 'MAD' On Your Local Newsstand... | promo (ad from the publisher) | 1 | pencils: Bill Elder; inks: Bill Elder | |
| 5 | Shermlock Shomes! | comic story | 8 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Shermlock Shomes; Dr. Whatsit; Cecil B. V. D. Mill (cameo); Mrs. Gowanus; a woman; the woman's uncle |
| 6 | Treasure Island! | comic story | 7 | script: Harvey Kurtzman; pencils: John Severin; inks: John Severin; colors: Marie Severin | Melvin of the Apes (cameo); Melvin Hawkins; Captain Rollem Bones; Long-John Aluminum; Melvin Mole (cameo) |
| 7 | We At E.C. Are Proudest of Our Science-Fiction Magazines | promo (ad from the publisher) | 0.5 | pencils: Frank Frazetta, Al Williamson; inks: Frank Frazetta, Al Williamson; colors: Marie Severin | |
| 8 | Operation Under-the-Ground [Chapter 1] | text story | 1 | script: Jerry DeFuccio | Five Fingers Jones; The Chief |
| 9 | E.C. comics | promo (ad from the publisher) | 0.5 | letters: typeset | |
| 10 | MAD Mumblings | letters page | 1 | script: Harvey Kurtzman | |
| 11 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 12 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 13 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 14 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 15 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 16 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 17 | Smilin' Melvin! | comic story | 7 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Smilin' Melvin; Upwind Johnson; Thatstuff |
| 18 | - | cover reprint (on interior page) | 1 | pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 19 | So What? So You, Too, Can Join the E.C. Fan-Addict Club! | promo (ad from the publisher) | 1 | pencils: Jack Davis; inks: Jack Davis | |
| 20 | Frank N. Stein! | comic story | 8 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Baron Francesco Napoleon Stein; Bumble; Melvin; Sherman; the monster |
| 21 | Lone Stranger Rides Again! | comic story | 7 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Lone Stranger; Pronto [Chief Wonga]; Ookabollwonga tribe |
| 22 | We at E.C. are Proudest of Our Science-Fiction Magazines! | promo (ad from the publisher) | 0.5 | pencils: Joe Orlando; inks: Joe Orlando; colors: Marie Severin | |
| 23 | Operation Under-the-Ground [Chapter II] | text story | 1 | script: Jerry DeFuccio | Five Fingers Jones; the Chief |
| 24 | Educational Comics, Inc. | promo (ad from the publisher) | 0.5 | letters: typeset | |
| 25 | - | letters page | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | |
| 26 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 27 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 28 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 29 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 30 | - | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 31 | Bat Boy and Rubin! | comic story | 7 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Bat Boy; Rubin; the Fleagle Gang; the Flurgle Gang |
| 32 | - | cover reprint (on interior page) | 1 | pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 33 | So What? So You, Too, Can Join The E.C. Fan-Addict Club! | promo (ad from the publisher) | 1 | pencils: Jack Davis; inks: Jack Davis | |
| 34 | Little Orphan Melvin! | comic story | 8 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Little Orphan Melvin; Daddy Peacebucks; Punjoke; Gravel; Ax L. Maxl; The Gasp!; Mommy Peacebucks |
| 35 | The Raven | comic story | 7 | script: Edgar Allan Poe, Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | a raven; the narrator; Lenore |
| 36 | - | letters page | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | |
| 37 | Yep Kiddies! E.C.'s New Humor Mag, Panic, Is On Sale | promo (ad from the publisher) | 1 | pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Melvin; Irving |
| 38 | Bop Jokes! | comic story | 6 | script: Harvey Kurtzman; pencils: John Severin; inks: John Severin; colors: Marie Severin | |
| 39 | Operation Under the Ground [Chapter 3] | text story | 1 | script: Jerry DeFuccio | Five Fingers Jones; Floppova Movova |
| 40 | Hah! Noon! | comic story | 7 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Marshall Kane; Mrs. Kane; Marshall Floodnick; Killer Diller Miller; Ramona |
| 41 | The Face Upon The Floor | cover reprint (on interior page) | 1 | pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Ben Oda | |
| 42 | I Dreamed I Went to a Fraternity Smoker in My Panic Magazine! | promo (ad from the publisher) | 1 | pencils: Jack Davis; inks: Jack Davis | |
| 43 | G.I. Shmoe! | comic story | 8 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Galusha Iggy Shmoe [G. I. Shmoe]; Sgt. Squirt; Comrade Commander |
| 44 | Sane! | comic story | 7 | script: Harvey Kurtzman; pencils: John Severin; inks: John Severin; colors: Marie Severin | Sane; Paw; Maw; Joey; Wilson |
| 45 | Operation Under-the-Ground Chapter 35 [Chapter 4] | text story | 0.67 | script: Jerry DeFuccio | Five Fingers Jones; Floppova Movova; Lavrenti Buried |
| 46 | Statement of Ownership | statement of ownership | 0.33 | script: Frank D. Lee | |
| 47 | You, Too, Can Meet New Friends! | promo (ad from the publisher) | 1 | pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | |
| 48 | MAD Mumblings | letters page | 1 | script: Harvey Kurtzman | |
| 49 | The Face Upon the Floor! | comic story | 6 | script: Harvey Kurtzman, H. Antoine D'Arcy; pencils: Jack Davis, Basil Wolverton; inks: Jack Davis, Basil Wolverton; colors: Marie Severin | the vagabond |
| 50 | Woman Wonder! | comic story | 7 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Woman Wonder [Diana Banana]; Steve Adore; Nivlem [a disguised Steve Adore]; Mickey; Spillane; Superduperman (cameo) |
| 51 | Beautiful Girl of the Month Reads MAD | cover reprint (on interior page) | 1 | pencils: Basil Wolverton; inks: Basil Wolverton | |
| 52 | Beware of Imitations! | promo (ad from the publisher) | 1 | pencils: Jack Davis; inks: Jack Davis | |
| 53 | Flesh Garden! | comic story | 8 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Flesh; Dale; an alien; Dr. Noah Zark; a Zork; a Zorchton; a Zilchtron; Owlmen; Rockmen; Treemen; Grassmen; Airmen; King Mong |
| 54 | MAD Reader! | comic story | 6 | script: Harvey Kurtzman; pencils: Basil Wolverton; inks: Basil Wolverton; colors: Marie Severin | |
| 55 | I Dreamed I Went to a Fraternity Smoker in My Panic Magazine! | promo (ad from the publisher) | 1 | pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | |
| 56 | Operation Under-the-Ground Chapter 87 [Chapter 5] | text story | 1 | script: Jerry DeFuccio | Five Fingers Jones; Lavrenti Buried; Floppova Movova |
| 57 | Murder the Husband! | comic story | 3 | script: Bill Gaines, Al Feldstein; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Walter Graham; Kenneth Martin |
| 58 | Murder the Story! | comic story | 3 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Cracker Graham; Melvin Martin |
| 59 | Beware of Imitations! | promo (ad from the publisher) | 1 | pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | |
| 60 | MAD Mumblings | letters page | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | |
| 61 | Dragged Net! | comic story | 7 | script: Harvey Kurtzman; pencils: Will Elder; inks: Will Elder; colors: Marie Severin | Joe Friday; Ed Saturday; Chief Mike Sunday; Shermlock Shomes (cameo); Dr. Whatsit (cameo); murderer; bank robber; Willie Elder |
| 62 | Special Issue | cover | 1 | letters: typeset | |
| 63 | Stoppit! | promo (ad from the publisher) | 1 | pencils: Will Elder; inks: Will Elder | |
| 64 | Starchie | comic story | 8 | script: Harvey Kurtzman; pencils: Will Elder; inks: Will Elder; colors: Marie Severin | Starchie Standrews; Bottleneck; Mr. Weathernot; Little Orphan Melvin (cameo); Cookie Bumstead (cameo); Salonica; Biddy; Wedgie Van Smelt; Mr. Standrews; Mrs. Standrews; Dick Tracy (cameo) |
| 65 | From Eternity Back to Here! | comic story | 7 | script: Harvey Kurtzman; pencils: Bernie Krigstein; inks: Bernie Krigstein; colors: Marie Severin | Sgt. Gaym Warden; Captain Sherlock Homes; Prew Prewitt; Mrs. Homes; Jodie Majjio; Fatso; Mrs. Kipper; Princess |
| 66 | Operation Under-the-Ground [Chapter 6] | text story | 1 | script: Jerry DeFuccio | Five Fingers Jones; Floppovo Movova; Lavrenti Buried |
| 67 | Do People Laugh at You for Reading Comic Books? | promo (ad from the publisher) | 1 | pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | |
| 68 | MAD Mumblings | letters page | 1 | script: Harvey Kurtzman | |
| 69 | 3-Dimensions! | comic story | 6 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | MAD writer; MAD artist |
| 70 | Mark Trade! | comic story | 7 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Mark Trade; Mr. Tamesplinter; Morsemere; Sandy; scouts |