| 0 | - | cover | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones | Yorick Brown; Ampersand |
| 1 | Y: The Last Man - Unmanned | credits, title page | 1 | pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo | Yorick Brown |
| 2 | - | credits, title page | 1 | pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo | Yorick Brown |
| 3 | Cover - Y: The Last Man #1 | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones; editing: Heidi MacDonald, Zachary Rau | Yorick Brown; Ampersand |
| 4 | Unmanned | comic story | 32 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo; letters: Clem Robins; editing: Heidi MacDonald, Zachary Rau | Yorick Brown; Ampersand; Hero Brown; Beth Deville; Congresswoman Jennifer Brown; Agent 355; Dr. Allison Mann; Colonel Alter Tse'Elon; Dr. Frozan Hamad (death); Michael Gilman (death); Marty; Tommy (death); Christopher (death); Joe (death); Larry (death); Darin (death); Agent 1033 (death) |
| 5 | Cover - Y: The Last Man #2 | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones; editing: Heidi MacDonald, Zachary Rau | Yorick Brown; Ampersand |
| 6 | Unmanned Chapter Two | comic story | 22 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo; letters: Clem Robins; editing: Heidi MacDonald, Zachary Rau | Yorick Brown; Ampersand; Margaret Valentine; Agent 355; Congresswoman Jennifer Brown; Diane |
| 7 | Cover - Y: The Last Man #3 | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones; editing: Heidi MacDonald, Zachary Rau | Yorick Brown |
| 8 | Unmanned Chapter Three | comic story | 22 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo; letters: Clem Robins; editing: Heidi MacDonald, Zachary Rau | Jennifer Brown; Yorick Brown; Ampersand; Senator Cavanaugh; Diane; President Margaret Valentine; Ms. Stahl; Colonel Alter Tse'Elon; Sadie; Sheila (death) |
| 9 | Cover - Y: The Last Man #4 | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones; editing: Heidi MacDonald, Zachary Rau | Yorick Brown |
| 10 | Unmanned Chapter Four | comic story | 22 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo; letters: Clem Robins; editing: Heidi MacDonald, Zachary Rau | Yorick Brown [also as Beth]; Ampersand; Agent 355; Fran; Rose; Victoria; Hero Brown |
| 11 | Cover - Y: The Last Man #5 | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones; editing: Steve Bunche | Yorick Brown |
| 12 | Unmanned Conclusion | comic story | 22 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo; letters: Clem Robins; editing: Steve Bunche | Yorick Brown; Ampersand; Agent 355; Victoria; Dr. Allison Mann; Hero Brown; Beth Deville (dream); Colonel Alter Tse'Elon; Sadie |
| 13 | Look for These Other Vertigo Books | promo (ad from the publisher) | 1 | letters: typeset | |
| 14 | Y: The Last Man - Unmanned | promo (ad from the publisher) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones | Yorick Brown |