| 0 | - | cover | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones | Yorick Brown |
| 1 | The End of the World As We Know It | recap | 1 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr. | Ampersand |
| 2 | Cover - Y: The Last Man #6 | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones; editing: Steve Bunche | Yorick Brown; Ampersand |
| 3 | Cycles Chapter One | comic story | 22 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo, Digital Chameleon; letters: Clem Robins; editing: Steve Bunche | Yorick Brown; Ampersand; Agent 355; Dr. Allison Mann; Daughters of the Amazon [Hero Brown; Victoria]; Natalya; Joanne |
| 4 | Cover - Y: The Last Man #7 | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones; editing: Steve Bunche | Daughters of the Amazon [Hero Brown; Victoria] |
| 5 | Cycles Chapter Two | comic story | 22 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo, Zylonol; letters: Clem Robins; editing: Steve Bunche | Yorick Brown; Ampersand; Sonia; Dr. Allison Mann; Agent 355; Daughters of the Amazon [Hero Brown; Victoria; Winona] |
| 6 | Cover - Y: The Last Man #8 | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones; editing: Steve Bunche | Sonia; Yorick Brown |
| 7 | Cycles Chapter Three | comic story | 22 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo; letters: Clem Robins; editing: Steve Bunche | Yorick Brown; Ampersand; Sonia; Dr. Allison Mann; Agent 355; Lydia; Tess; Daughters of the Amazon [Hero Brown; Victoria] |
| 8 | Cover - Y: The Last Man #9 | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones; editing: Steve Bunche | Ampersand; Yorick Brown |
| 9 | Cycles Chapter Four | comic story | 22 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo, Digital Chameleon; letters: Clem Robins; editing: Steve Bunche | Yorick Brown; Ampersand; Sonia (dies); Dr. Allison Mann; Agent 355; Lydia; Tess; Daughters of the Amazon [Hero Brown; Victoria (dies)] |
| 10 | Cover - Y: The Last Man #10 | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones; editing: Steve Bunche | Yorick Brown; Ampersand; Hero Brown |
| 11 | Cycles Conclusion | comic story | 22 | script: Brian K. Vaughan; pencils: Pia Guerra; inks: José Marzán Jr.; colors: Pamela Rambo, Zylonol; letters: Clem Robins; editing: Steve Bunche | Yorick Brown; Ampersand; Dr. Allison Mann; Agent 355; Lydia; Tess; Daughters of the Amazon [Hero Brown]; Sadie; Lt. General Tse'Elon; Representative Jennifer Brown; Dr. Ciba Weber (cameo); Vladimir (cameo); Joe (cameo) |
| 12 | Y: The Last Man | illustration | 9 | pencils: Pia Guerra | Yorick Brown; Beth Deville; Agent 355; Dr. Allison Mann; Sadie; Daughters of the Amazon; Dr. Frozan Hamad |
| 13 | Backcover | promo (ad from the publisher) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones | Yorick Brown; Ampersand; Sonia |