| 0 | - | cover | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | Alfred E. Neuman |
| 1 | - | promo (ad from the publisher) | 1 | letters: typeset | |
| 2 | - | table of contents | 1 | letters: typeset | |
| 3 | Letters We Sure Could Do Without | text story | 0.67 | letters: ?; typeset | |
| 4 | - | statement of ownership | 0.2 | script: William M. Gaines | |
| 5 | The Mad Suburban Primer | comic story | 4 | script: Stan Hart; pencils: Bob Clarke; inks: Bob Clarke | |
| 6 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 7 | When Teenagers Take Over TV Completely | comic story | 3 | script: Larry Siegel; pencils: Jack Rickard; inks: Jack Rickard | Paul McCartney; Jim McKay; Chet Huntley; David Brinkley, Curt Gowdy; Bill Flemming |
| 8 | At the Elevators | comic story | 2 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 9 | Voyage to See What's On the Bottom | comic story | 6 | script: Dick DeBartolo; pencils: Mort Drucker; inks: Mort Drucker | Richard Basehart [as Adm. Neilsen]; Huckleberry Hound (cameo); Quick Draw McGraw (cameo); David Hedison [as Comm. Leak Crane]; Terry Becker [as Chief Sharkey]; Popeye (cameo) |
| 10 | Spy Vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 11 | The Mad Treasury of Unknown Poetry | comic story | 2 | script: Tom Koch; pencils: Jack Rickard; inks: Jack Rickard | David Janssen [as Dr. Richard Kimble]; Wilt Chamberlain |
| 12 | The Lighter Side of Shopping | comic story | 4 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 13 | One Day in the Pasture | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 14 | Badge & Billy | comic story | 5 | script: Larry Siegel; pencils: George Woodbridge; inks: George Woodbridge | |
| 15 | Mad's Puzzle Page | activity | 2 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; letters: Al Jaffee | |
| 16 | Intimidations and Antidotes | comic story | 4 | script: Stan Hart; pencils: Joe Orlando; inks: Joe Orlando | |
| 17 | Spy Vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 18 | College Programs to Develop Masters of Mediocrity | comic story | 4 | pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 19 | The Sinpiper | comic story | 5 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | Elizabeth Taylor [as Lurid Reynard]; Richard Burton [as Dr. Egbert Hooey]; Eva Marie Saint [as Clear Hooey]; Charles Bronson [as the angry beatnik sculptor]; Morgan Mason [as Denny Reynard]; Eddie Fisher |
| 20 | Another Great Bank Robbery | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 21 | How Do Bosses Plan To Celebrate Future Office Xmas Parties | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |
| 22 | The Day the Wrong Giant Came Out of the Washer | photo story | 1 | letters: typeset | |