| 0 | Mad Proudly Presents Its 100th Issue | cover | 1 | letters: typeset | Alfred E. Neuman |
| 1 | Future Broadway Musicals | comic story | 5 | script: Frank Jacobs; pencils: Jack Rickard; inks: Jack Rickard | Gregory Peck [as Captain Ahab]; Dean Martin [as Sydney Carton]; Frank Sinatra [as Charles Darney]; Shirley MacLaine [as Lucie Manette]; Richard Burton [as Tarzan]; Elizabeth Taylor [as Jane Porter] |
| 2 | The Wonderful World of Repackaging | comic story | 3 | script: Dick DeBartolo; pencils: Bob Clarke; inks: Bob Clarke | |
| 3 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 4 | Spy Vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 5 | The Nilson Family | comic story | 5 | script: Stan Hart; pencils: Mort Drucker; inks: Mort Drucker | Ozzie Nelson [as Oosie Nilson]; Harriet Nelson [as Harried Nilson]; Rick Nelson [as Ricketty Nilson]; David Nelson [as Divot Nilson]; Skip Young [as Whaley] |
| 6 | The Return of the Mad Beasties | comic story | 2 | script: Phil Hahn; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 7 | The Lighter Side of Sleep | comic story | 4 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 8 | What Is a Blind Date? | text story | 2 | script: Arnie Kogen; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 9 | Shirley Finster's New York | comic story | 4 | script: Ronald Axe, Sol Weinstein; pencils: George Woodbridge; inks: George Woodbridge | Shirley Finster |
| 10 | Mad's Puzzle Page | activity | 2 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; letters: Al Jaffee | |
| 11 | Mad's Modern Believe It or Nuts | cartoon | 1 | pencils: Bob Clarke; inks: Bob Clarke; letters: Bob Clarke | |
| 12 | The Toy Manufacturer of the Year | comic story | 5 | script: Stan Hart; pencils: Joe Orlando; inks: Joe Orlando | Chet Huntley [as Chet Hunkley] |
| 13 | Spy Vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 14 | The Swan Song of a Modern Hiawatha | comic story | 4 | script: Tom Koch; pencils: Don Martin; inks: Don Martin | Hiawatha; Coach Kowalski |
| 15 | Hack, Hack, Sweet Has-Been, or Whatever Happened to Good Taste? | comic story | 5 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | Snoopy (cameo); Olivia de Havilland [as Cousin Phoebe]; Bette Davis [as Bubby Jean]; Joan Crawford [as Honeybunch]; Tallulah Bankhead [as Precious]; Barbara Stanwyck [as Poopy]; Mary Astor [as Kitchykoo]; Agnes Moorehead [as Charlie]; Victor Buono [as Papa]; Joseph Cotton [as Selig]; Annette Funicel |
| 16 | On the Subway | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 17 | A Vital Message From the Staff of Mad | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |
| 18 | The Replacement | comic story | 1 | script: Don Edwing; pencils: Bob Clarke; inks: Bob Clarke; colors: Bob Clarke | |