| 0 | I will never read class in Mad | cover | 1 | pencils: Bob Clarke; inks: Bob Clarke; colors: Bob Clarke | Alfred E. Neuman |
| 1 | A Hawk's-Eye View of the United States | illustration | 1 | script: Max Brandel; pencils: Bob Clarke; inks: Bob Clarke; colors: Bob Clarke | |
| 2 | Why Not Have the Next Issue Sent Directly to Your Home? | promo (ad from the publisher) | 0.67 | script: Nick Meglin; pencils: Paul Coker; inks: Paul Coker | |
| 3 | The Guru of Ours | comic story | 7 | script: Frank Jacobs; pencils: Mort Drucker; inks: Mort Drucker | Liza Minnelli [as Dorothy]; Tiny Tim [as Auntie Em]; Dustin Hoffman [as The Munchkin King]; Pat Boone [as The Square]; George Hamilton [as The Snob]; Schroeder (cameo); Michael J. Pollard [as The Psycho]; Ed Sullivan [as The Guru] |
| 4 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 5 | On a Saturday Afternoon | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 6 | A Mad Nature Study Guide | photo story | 3 | script: Max Brandel, Frank Jacobs | Jane Fonda; Spiro Agnew; Richard Burton; Elizabeth Taylor; Bob Dylan; Mao tse-Tung; Doris Day; Fidel Castro; Tiny Tim; Gamel Abdel Nasser; Charles DeGaulle; Adam Clayton Powell |
| 7 | The Heart Transplant | comic story | 2 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |
| 8 | Mad's "Foreign Film Producer of the Year" | comic story | 4 | script: Dick DeBartolo; pencils: Joe Orlando; inks: Joe Orlando | Hugh Downs; Carlo Levinetini |
| 9 | One Day in a Hospital 2 | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 10 | You Know You're Really Overweight When... | comic story | 2 | script: Jack Kent; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 11 | Mad's All-Inclusive Do-It-Yourself Protest Newspaper Story | text story | 2 | script: Frank Jacobs | |
| 12 | The Lighter Side of Amusement Parks | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 13 | Spy vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 14 | Some "Greeting Cards to the Newlyweds" We'd Like to See | comic story | 3 | script: Frank Jacobs, David Hunter; pencils: Bob Clarke; inks: Bob Clarke | |
| 15 | One Day in a Sawmill | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 16 | A Mad Peek Behind the Scenes: At a Laundry & Dry Cleaners | cartoon | 2 | script: Larry Siegel; pencils: Jack Davis; inks: Jack Davis | |
| 17 | A Mad Portfolio of Appropriate Comic Strip Sound Effects | comic story | 3 | script: Earle Doud; pencils: Bob Clarke; inks: Bob Clarke; letters: Bob Clarke | Mammy Yokum; Pappy Yokum; Dennis Mitchell; Henry Mitchell; Archie Andrews; Jughead Jones; Mr. A. Mutt; Jeff; Charlie Brown; Dagwood Bumstead; Mr. Dithers; Daddy Warbucks; Beetle Bailey; Mary Perkins; Dick Tracy |
| 18 | The Heist | comic story | 2 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 19 | A Mad Look at Two College Generations | comic story | 5 | script: Larry Siegel; pencils: George Woodbridge; inks: George Woodbridge | |
| 20 | What Is the One Unhappiness Almost All Modern Parents Are Sure to Share with Their Children? | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 21 | The Tomb of the Unknown Smoker | illustration | 1 | script: Max Brandel; pencils: Irving Schild; inks: Irving Schild; colors: Irving Schild | |