| 0 | Alfred E. Neuman, Mad's "Write-In" Candidate for President | cover | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | Alfred E. Neuman |
| 1 | Mad Super Special Winter 1980 | promo (ad from the publisher) | 1 | | Alfred E. Neuman |
| 2 | Table of Contents | table of contents | 1 | letters: typeset | |
| 3 | Mad Magazine Resents Throw Up the Academy | comic story | 2 | script: Stan Hart; pencils: Angelo Torres; inks: Angelo Torres | Sal; Vito |
| 4 | Being Not All There | comic story | 7 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | Mrs. Gravnick; Alan Hale [as Skipper] (cameo); Bob Denver [as Gilligan] (cameo); Fred Rogers (cameo); Popeye (cameo); Bluto (cameo); Olive Oyl (cameo); J. Wellington Wimpy (cameo); Fred Flintstone (cameo); Peter Sellers [as Trance]; Ruth Attaway [as Luwheeze]; Mr. Lemming (deceased); Shirley MacLain |
| 5 | Don Martin Dept. Part I: One Day in the Life of a Tennis Pro | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 6 | A Collection of Mad X-Rayvings | comic story | 3 | script: Don Edwing; pencils: Bob Clarke; inks: Bob Clarke | |
| 7 | The Mad Nasty Book Volume Two | comic story | 3 | script: Tom Koch; pencils: Harry North; inks: Harry North | Ku Klux Klan; Mork; Jane Fonda; Dolly Parton; Cher; Mike Wallace; Pete Rose |
| 8 | The Lighter Side of... | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 9 | Sneaky Mad Tactics to Get People to Open "Junk Mail" | text story | 3 | script: Dick DeBartolo | |
| 10 | A Mad Guide to Cheap Pastimes | comic story | 3 | script: Paul Peter Porges; pencils: Paul Peter Porges; inks: Paul Peter Porges | |
| 11 | Advertising Makes You Wonder... | comic story | 4 | script: Tom Koch; pencils: Jack Davis; inks: Jack Davis | |
| 12 | Glass Shattered by Singing | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías; letters: Antonio Prohías | Black Spy; White Spy |
| 13 | The Mad Dictionary of Cliche Parental Terms | comic story | 4 | script: Barry Liebmann; pencils: Paul Coker; inks: Paul Coker | |
| 14 | Don Martin Dept. Part III: One Day in the Life of Some Salesmen | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | Fonebone |
| 15 | Who Knows What Evils Lurk in the Hearts of Men? The Shadow Knows | comic story | 3 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 16 | WKRAP in Cincinnati | comic story | 6 | script: Arnie Kogen; pencils: Angelo Torres; inks: Angelo Torres | Gary Sandy [as Antsy]; Gordon Jump [as Arthur Curlson]; Loni Anderson [as Juniper]; Minnie Pearl (cameo); Howard Hesseman [as Dr. Johnny Frantic]; Tim Reid [as Venus Fly Paper]; Frank Bonner [as Nerve]; Richard Sanders [as Mess]; Jan Smithers [as Bully]; Nipper (cameo); Sonny Bono (cameo); Jim Nabor |
| 17 | What's the Most Exciting Thing on TV Today! | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | Buck Rogers; Twiki; Hulk; Ponch [Officer Francis Llewellyn Poncherello]; Charlie's Angels; John Bosley; J.R. Ewing |
| 18 | Checks Cashed | comic story | 1 | script: Don Edwing; pencils: Don Martin; inks: Don Martin | |
| 19 | Drawn-Out Dramas | comic story | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; letters: Sergio Aragonés | |