| 0 | We Mutate X-Men 2 | cover | 1 | pencils: Mark Stutzman; inks: Mark Stutzman | Alfred E. Neuman |
| 1 | Departments | table of contents | 1 | pencils: various; inks: various; colors: various; letters: typeset | |
| 2 | - | letters page | 3 | pencils: various; inks: various; colors: various; letters: typeset | |
| 3 | $-Men 2 | comic story | 8 | script: Desmond Devlin; pencils: Tom Richmond; inks: Tom Richmond | Patrick Stewart [as Professor $]; James Marsden [as Cyclod]; Halle Berry [as Deform]; Hugh Jackman [as Vasoline]; Anna Paquin [as Rogaine]; Famke Jannsen [as Jean Greypoupon]; Ian McKellen [as Magnesia]; Rebecca Romijn-Stamos [as Physique]; Bruce Davison [as Senator Jefferson Smelly]; Shawn Ashmore |
| 4 | Splash Me If You Can | comic story | 1 | script: Duck Edwing; pencils: Duck Edwing; inks: Duck Edwing; letters: Duck Edwing | |
| 5 | Monroe and... the Brain | comic story | 4 | script: Anthony Barbieri; pencils: Bill Wray; inks: Bill Wray; letters: Bill Wray | |
| 6 | Mad's Complete Guide to Plagiarism | comic story | 3 | script: Mike Snider; pencils: Kevin Pope; inks: Kevin Pope | |
| 7 | The Jerry Springer Spaniel Show | comic story | 2 | script: Teresa Burns Parkhurst; pencils: Teresa Burns Parkhurst; inks: Teresa Burns Parkhurst; letters: Teresa Burns Parkhurst | |
| 8 | Spy vs Spy | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper | The Black Spy, The White Spy |
| 9 | Firsthand Evidence That Obesity in Your School May Be Out of Control! | comic story | 3 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell | |
| 10 | Mad Deconstructs TV Talk Shows This Month: The View | comic story | 3 | script: Desmond Devlin; pencils: Mort Drucker; inks: Mort Drucker | |
| 11 | A Prom Night Scrapbook for a Gay Couple in Smalltown, U.S.A. | comic story | 4 | script: Mike Snider; pencils: Hermann Mejía; inks: Hermann Mejía | |
| 12 | Lojerk Stolen Vehicle Recovery System | comic story | 1 | script: Jeff Kruse; pencils: Timothy Shamey; inks: Timothy Shamey | |
| 13 | A Mad Look at Mothers | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; letters: Sergio Aragonés | |
| 14 | Duke Bissell's Tales of Undisputed Interest | comic story | 1 | script: P. C. Vey; pencils: P. C. Vey; inks: P. C. Vey; letters: P. C. Vey | |
| 15 | Mad's Unreal Outtakes from the Matrix Reloaded | photo story | 2 | script: Greg Leitman | |
| 16 | Subtle Indications That the Guy You're Dating May Not Be a Millionaire | comic story | 2 | script: John Prete; pencils: Rick Tulka; inks: Rick Tulka | |
| 17 | Mad's Spam of the Month - Magic Meat Enhancer | photo story | 2 | script: Dick DeBartolo; pencils: Irving Schild; inks: Irving Schild; colors: Irving Schild | |
| 18 | What Extreme Sport Will Many Youths Soon Take Part In? | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |