| 0 | Viva La Stupidity! | cover | 1 | letters: typeset | Alfred E. Neuman |
| 2 | Departments | table of contents | 1 | pencils: various; inks: various; letters: typeset | George W. Bush, Hillary Clinton, Alfred E. Neuman |
| 3 | Random Samplings of Reader Mail | letters page | 1.67 | script: John Ficarra | Alfred E. Neuman |
| 5 | - | credits, title page | 0.33 | letters: typeset | |
| 6 | Own A Piece Of MAD History! | promo (ad from the publisher) | 1 | pencils: Kelly Freas; inks: Kelly Freas; colors: Kelly Freas | Alfred E. Neuman |
| 7 | The Fundalini Pages | comic story | 3 | script: various (see notes); pencils: various (see notes); inks: various (see notes); letters: typeset | Fidel Castro, Roger Clemens, Bill Clinton, Hillary Clinton, John Rambo |
| 9 | Zeroes | comic story | 5 | script: Desmond Devlin; pencils: Tom Richmond; inks: Tom Richmond | Sendhil Ramamurtry [as Longwindy Smersh]; Masi Oka [as Neato Geekarama]; Adrian Pasdar [as Nabob Porkbelly]; Milo Ventimiglia [as Putter Porkbelly]; Ali Larter [as Sicki]; Leonard Portman [as B.S.]; Greg Grunberg [as Fatt Porkman]; Hayden Panettiere [as Stare Bennet]; Jack Coleman [as Mr. Bennet]; M |
| 10 | Millions of Trees Gave Their Lives For These Books | promo (ad from the publisher) | 1 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | |
| 11 | The Darker Side of The Lighter Side | comic story | 3 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | Dave Berg |
| 12 | Monroe and...High School Musical | comic story | 4 | script: Anthony Barbieri; pencils: Tom Fowler; inks: Tom Fowler; colors: Ryan Flanders | Monroe; principal; Dylan; Walter; Mr. McClammy; Monroe's father; Monroe's mother |
| 13 | Zygote 101 | illustration | 1 | pencils: Scott Bricher; inks: Scott Bricher; colors: Scott Bricher | Jamie Lynn Spears |
| 15 | If Classic Old Movie Scenes Were Filmed Today | comic story | 2 | script: Dick DeBartolo; pencils: Hermann Mejía; inks: Hermann Mejía | |
| 16 | Planet Tad!!!!! | comic story | 2 | script: Tim Carvell; pencils: Brian Durniak; inks: Brian Durniak | Jabba the Hutt, Lady, Tramp |
| 17 | Spy Vs. Spy | comic story | 1 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper | The Black Spy, The White Spy |
| 18 | Why George W. Bush Is In Favor of Global Warming | comic story | 3 | script: Jacob Lambert; pencils: Jack Higgins, Dick Locher, Matt Davies, Clay Bennett, Michael Ramirez, Ben Sargent; inks: Jack Higgins, Dick Locher, Matt Davies, Clay Bennett, Michael Ramirez, Ben Sargent; letters: Jack Higgins, Dick Locher, Matt Davies, Clay Bennett, Michael Ramirez, Ben Sargent | George W. Bush |
| 19 | Extremist Makeover Politician Edition | comic story | 2 | script: Jeff Kruse; pencils: Drew Friedman; inks: Drew Friedman; colors: Drew Friedman | Hillary Clinton, Barack Obama |
| 20 | MAD's Bat-tastic The Dark Knight Outtakes | comic story | 2 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | Batman, Commissioner James Gordon, Joker, Jack Napier, Bruce Wayne |
| 21 | A MAD Look At Halo | comic story | 3 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 22 | A Gigantic Collection | promo (ad from the publisher) | 1 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | Alfred E. Neuman |
| 23 | American Gagster | comic story | 5 | script: Arnie Kogen; pencils: Mort Drucker; inks: Mort Drucker | Denzel Washington [as Crank Locust]; Russell Crowe [as Itchy Conners]; Clarence Williams III [as Ellswood "Burpy" Jackson]; Cuba Gooding Jr.; Ruby Dee [as Mama Locust]; Lymari Nadal [as Miss Puerto Rico]; Josh Brolin [as Detective Lupo]; Idris Elba [as Tempo]; Snoopy (cameo) |
| 24 | On Sale Now! | promo (ad from the publisher) | 1 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | Mario |
| 25 | What The Heck Is The Difference? | activity | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | Fidel Castro |
| 26 | What Major Star Has Recently Admitted Receiving Illegal Career-Damaging Human Growth Injections? | activity | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | Jamie Lynn Spears |
| 27 | Drawn-Out Dramas | comic story | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |