| 0 | American Scream | cover | 1 | pencils: Mark Fredrickson; inks: Mark Fredrickson; colors: Mark Fredrickson | |
| 1 | - | table of contents | 2 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 2 | A TV Commercial We'd Like to See | comic story | 1 | script: Billy Doherty; pencils: Angelo Torres; inks: Angelo Torres | Richard M. Nixon; Ollie North; Ronald Reagan |
| 3 | A Mad Look at Politics | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Carrie Strachan; letters: Sergio Aragonés | |
| 4 | Mad Magazine's Ideal Presidential Candidate | photo story | 3 | script: Lou Silverstone, Max Brandel; pencils: Max Brandel; inks: Max Brandel | Lyndon Johnson; Eugene McCarthy; Ronald Reagan; Hubert Humphrey; Mark Hatfield; Nelson Rockefeller; Dwight Eisenhower; Richard Nixon; John Lindsey; Charles Percy |
| 5 | - | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper; colors: Peter Kuper; letters: Peter Kuper | |
| 6 | White House Corruption | illustration | 1 | script: Tammy Golden; pencils: Paul Wee; inks: Paul Wee; colors: Paul Wee | |
| 7 | SuperDelegate | comic story | 2 | script: Joe Raiola; pencils: R. Sikoryak; inks: R. Sikoryak | Bill Clinton; Hillary Clinton; Barack Obama; Michelle Obama |
| 8 | One Day at Mount Rushmore | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin; colors: Carl Peterson | |
| 9 | The Fascist & the Feeblest | comic story | 5 | script: Desmond Devlin; pencils: Tom Richmond; inks: Tom Richmond; colors: Tom Richmond | |
| 10 | The Great Trump Bestiary | comic story | 2 | script: David Seidman; pencils: Leonardo Rodriguez; inks: Leonardo Rodriguez; colors: Leonardo Rodriguez | |
| 11 | More Helpful Ways the Government Can Track Women's Lives | comic story | 2 | script: Teresa Burns Parkhurst; pencils: Teresa Burns Parkhurst; inks: Teresa Burns Parkhurst; colors: Teresa Burns Parkhurst | |
| 12 | What is a Hollywood Liberal? | comic story | 2 | script: Mike Snider; pencils: Rick Tulka; inks: Rick Tulka | |
| 13 | Garbage Pail Politicos | comic story | 2 | script: Paula Sevenbergen; pencils: Brent Engstrom; inks: Brent Engstrom; colors: Brent Engstrom | |
| 14 | Democratic Madvent Calendar | comic story | 2 | script: Amanda Stellberg; pencils: Tom Richmond; inks: Tom Richmond | |
| 15 | Elephant & Donkey by Mo' Problems | comic story | 2 | script: Brandon Hicks; pencils: Dalton Vaughn; inks: Dalton Vaughn | |
| 16 | The Day AT&T Went Too Far | comic story | 1 | script: John Prete; pencils: Harvey Kurtzman, Will Elder; inks: Harvey Kurtzman, Will Elder | Ronald Reagan; Mikhail Gorbachev |
| 17 | Only a Republican/Democrat Could Possibly Believe… | comic story | 2 | script: Russ Cooper; pencils: Paul Coker; inks: Paul Coker; colors: Carl Peterson | |
| 18 | Mad's Snappy Answers to Stupid Questions 2024 Election Edition | comic story | 2 | script: Johnny Sampson; pencils: Johnny Sampson; inks: Johnny Sampson | |
| 19 | Trump on Twitter | illustration | 1 | pencils: Mike Loew; inks: Mike Loew | President Donald Trump |
| 20 | The Bailout Hymn of the Republic | comic story | 3 | script: Frank Jacobs; pencils: Mort Drucker, James Warhola, Tom Richmond, Angelo Torres, Hermann Mejía, Gerry Gersten; inks: Mort Drucker, James Warhola, Tom Richmond, Angelo Torres, Hermann Mejía, Gerry Gersten | Barack Obama; Nancy Pelosi; Senator Shelby; Chris Dodd; Barney Frank; Alfred E. Neuman; Black Spy; White Spy; Monroe |
| 21 | The Ballot | comic story | 1 | script: Kenny Smith; pencils: Ed Steckley; inks: Ed Steckley | |
| 22 | Horrifying Political Cliches | comic story | 2 | script: Frank Jacobs; pencils: Paul Coker; inks: Paul Coker; colors: Carl Peterson | |
| 23 | Extremist Makeover Politician Edition | comic story | 2 | script: Jeff Kruse; pencils: Drew Friedman; inks: Drew Friedman; colors: Drew Friedman | Barack Obama; Hillary Clinton; John Edwards; Mitt Romney; Mike Huckabee; Rudolph Giuliani; Ty Pennington |
| 24 | The Ghastlygun Tinies | comic story | 4 | script: Matt Cohen; pencils: Marc Palm; inks: Marc Palm; letters: Marc Palm | |
| 25 | Vote Neuman Campaign Mailer | text article | 1 | script: Dick DeBartolo; pencils: Mark Fredrickson; inks: Mark Fredrickson | |
| 26 | A TV Ad We'll Soon See | comic story | 1 | script: Christian Alsis; pencils: Hermann Mejía; inks: Hermann Mejía | |
| 27 | The Times They Aren't a Changin' Dept. | comic story | 1 | script: Frank Jacobs, Stan Hart; pencils: Jack Davis; inks: Jack Davis | |
| 28 | Which White House Appliance Gets the Most Use? | activity | 1 | script: Johnny Sampson; pencils: Johnny Sampson; inks: Johnny Sampson; colors: Johnny Sampson | |
| 29 | Don't Vote for Alfred E. Neuman for President | illustration | 1 | pencils: Norman Mingo; inks: Norman Mingo | Alfred E. Neuman |