| 0 | Mad Science | cover | 1 | pencils: Terry Wolfinger; inks: Terry Wolfinger; colors: Terry Wolfinger | |
| 1 | - | table of contents | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | Alfred E. Neuman |
| 2 | A Mad Look at Mutant Monsters | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Carrie Strachan; letters: Sergio Aragonés | |
| 3 | Dr. Jekyll and Mr. Hyde | comic story | 2 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 4 | - | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper; colors: Peter Kuper; letters: Peter Kuper | |
| 5 | A Mad Peek Through the Microscope | comic story | 2 | script: Phil Hahn; pencils: Bob Clarke; inks: Bob Clarke | |
| 6 | Frank N. Stein! | comic story | 8 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin; letters: Ben Oda | Baron Francesco Napoleon Stein; Bumble; Melvin; Sherman; the monster |
| 7 | Scenes We'd Like to See: The Monster and the Villagers | comic story | 1 | script: E. Nelson Bridwell; pencils: Joe Orlando; inks: Joe Orlando | Frankenstein's monster |
| 8 | Everyday Annoyances of Elderly Monsters | comic story | 2 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell | |
| 9 | Frankenstein’s Monster | comic story | 2 | script: Duck Edwing; pencils: Dave Manak; inks: Dave Manak; letters: Dave Manak | |
| 10 | One Fine Day in the Animal Testing Lab | comic story | 1 | script: Michael Gallagher; pencils: Paul Coker; inks: Paul Coker; letters: Paul Coker | |
| 11 | The Horror of Quack-enstein! | comic story | 4 | script: Desmond Devlin; pencils: Tom Richmond; inks: Tom Richmond; colors: Tom Richmond | |
| 12 | One Dark Night in a Laboratory | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 13 | The Man of Science | comic story | 4 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | Charlie Brown, Tony Curtis, Doris Day, Dennis the Menace, William Frawley |
| 14 | Has Your Food Been Genetically Altered? | comic story | 3 | script: Tom Cheney; pencils: Tom Cheney; inks: Tom Cheney | |
| 15 | A Boy and His Chemistry Set | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin; colors: Carrie Strachan | |
| 16 | Another Mad Peek Through the Microscope | comic story | 3 | script: Phil Hahn; pencils: Bob Clarke; inks: Bob Clarke | |
| 17 | Genetics and You! | comic story | 2 | script: Tammy Golden; pencils: Bob Fingerman; inks: Bob Fingerman; colors: Bob Fingerman | |
| 18 | Frankenslime | comic story | 5 | script: Dick DeBartolo; pencils: Angelo Torres; inks: Angelo Torres | Kenneth Branagh [as Vicgore Frankenslime]; John Cleese [as Professor Wildman]; Tom Hulce [as Hernia]; Helena Bonham Carter [as Lizbits]; Bugs Bunny (cameo) |
| 19 | The U.S. Czar of Science | comic story | 1 | script: Bill Jensen; pencils: Hermann Mejía; inks: Hermann Mejía; colors: Hermann Mejía | |
| 20 | - | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías; colors: Carrie Strachan | The Black Spy; The White Spy |
| 21 | Scenes We'd Like to See: The Bride of Frankenstein | comic story | 1 | script: Duck Edwing; pencils: Jack Davis; inks: Jack Davis | |
| 22 | You May Have Been a Test-Tube Baby If... | comic story | 0.67 | script: Desmond Devlin; pencils: Duck Edwing; inks: Duck Edwing | |
| 23 | What Has Caused a Dramatic Rise in Mad Scientists? | activity | 1 | script: Johnny Sampson; pencils: Johnny Sampson; inks: Johnny Sampson; colors: Johnny Sampson | |
| 24 | One-On-One Night in the Laboratory | comic story | 1 | script: Duck Edwing; pencils: Don Martin; inks: Don Martin | Frankenstein's Monster; Dr. Frankenstein; Igor |