| 0 | - | cover | 1 | pencils: Skottie Young; inks: Skottie Young; colors: Skottie Young | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Pete Woods; inks: Nathan Massengill | Deadpool; Weasel |
| 2 | With Great Power Comes Great Coincidence | comic story | 50 | script: Joe Kelly, Stan Lee; pencils: Pete Woods, John Romita; inks: Nathan Massengill, Al Milgrom, Joe Sinnott, John Romita; colors: Chris Sotomayor, Digital Chameleon; letters: Richard Starkings, Comicraft, Emerson Miranda | Deadpool; Blind Al; Weasel; Spider-Man [Peter Parker]; Aunt May Parker; Anna Watson; Mary Jane Watson; Gwen Stacy; Flash Thompson; Harry Osborn; Norman Osborn; Watcher; Lightning Rods [Great Lakes Avengers] [Flatman; Mr. Immortal; Doorman; Big Bertha; Dinah Soar]; Kraven the Hunter (villain) |
| 3 | Sticky Situations | cover reprint (on interior page) | 1 | pencils: Patrick Zircher; inks: M3TH of Udon; colors: Rob Schwager | Deadpool; Spider-Man |
| 4 | Sticky Situations | comic story | 22 | script: Fabian Nicieza; pencils: Patrick Zircher; inks: M3th, Udon; colors: Gotham; letters: Cory Petit, Virtual Calligraphy | Cable [Nathan Summers]; Deadpool [Wade Wilson]; Spider-Man [Peter Parker]; Irene Merryweather; Black Box [Gareb Bashur]; Ken Ellis; Robbie Robertson; J. Jonah Jameson; Nick Fury (cameo); Captain America [Steve Rogers] (cameo) |
| 5 | - | cover reprint (on interior page) | 1 | pencils: Skottie Young; inks: Skottie Young; colors: Skottie Young | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 6 | This Man, This Expletive Deleted | comic story | 22 | script: Joe Kelly; pencils: Eric Canete; inks: Eric Canete; colors: Andres Mossa; letters: Virtual Calligraphy, Joe Caramagna | Spider-Man; Deadpool; Madame Web; VILLAINS: Lady Stilt-Man; Kraven [Ana Kravinoff]; Sasha Nikolaevich; CAMEOS: J. Jonah Jameson; Michele Gonzales; Arana; Eddie Brock [Anti-Venom]; Spider-Woman [Mattie Franklin]; Prostitutes dressed as Emma Frost; Mystique; Elektra; Madame Masque; Enchantress; Black |
| 7 | - | cover reprint (on interior page) | 1 | pencils: Skottie Young; inks: Skottie Young; colors: Skottie Young | Spider-Man; Deadpool |
| 8 | - | cover reprint (on interior page) | 1 | pencils: Jason Pearson; inks: Jason Pearson; colors: Jason Pearson | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 9 | Whatever a Spider Can, Part 1: Start Spreadin' the News | comic story | 22 | script: Daniel Way; pencils: Carlo Barberi; inks: Juan Vlasco, Sandu Florea; colors: Marte Gracia; letters: Virtual Calligraphy, Joe Sabino | Deadpool; Spider-Man; Robbie Robertson; Hit-Monkey |
| 10 | - | cover reprint (on interior page) | 1 | pencils: Jason Pearson; inks: Jason Pearson; colors: Jason Pearson | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Hit-Monkey |
| 11 | Whatever a Spider Can Part 2 of 3 | comic story | 22 | script: Daniel Way; pencils: Carlo Barberi; inks: Sandu Florea; colors: Marte Gracia; letters: Virtual Calligraphy, Joe Sabino | Deadpool; GUEST: Spider-Man; VILLAIN: Hit-Monkey |
| 12 | - | cover reprint (on interior page) | 1 | pencils: Jason Pearson; inks: Jason Pearson; colors: Jason Pearson | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Hit-Monkey |
| 13 | Whatever a Spider Can Part 3 of 3 | comic story | 22 | script: Daniel Way; pencils: Carlo Barberi; inks: Sandu Florea; colors: Marte Gracia; letters: Virtual Calligraphy, Joe Sabino | Deadpool; Spider-Man; Fantastic Four [Mr. Fantastic; Invisible Woman; Human Torch; The Thing];Hit-Monkey (villain) |
| 14 | - | cover reprint (on interior page) | 1 | pencils: Shane Davis; inks: Mark Morales; colors: Matt Hollingsworth | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 15 | - | comic story | 20 | script: Kevin Shinick; pencils: Aaron Kuder; inks: Aaron Kuder; colors: Matt Hollingsworth; letters: VC, Joe Caramagna | Spider-Man [Peter Parker]; Deadpool; Hypno-Hustler (cameo) |
| 16 | - | cover reprint (on interior page) | 1 | pencils: Shane Davis; inks: Mark Morales; colors: Matt Hollingsworth | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Hypno-Hustler |
| 17 | - | comic story | 20 | script: Kevin Shinick; pencils: Aaron Kuder; inks: Aaron Kuder; colors: Matt Hollingsworth; letters: VC, Joe Caramagna | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Hypno-Hustler; Tinkerer; Boomerang [appears as Green Goblin]; ? [appears as Kraven the Hunter]; The Painter [appears as Morlun] |
| 18 | - | cover reprint (on interior page) | 1 | pencils: Tradd Moore; inks: Tradd Moore; colors: Edgar Delgado | Deadpool; Spider-Man [Superior Spider-Man; Otto Octavius] |
| 19 | Recap, credits and indicia | recap | 1 | script: Jordan D. White; pencils: Mike Hawthorne; inks: Mike Hawthorne; colors: Val Staples; letters: Joe Sabino | Deadpool; Emily Preston; Vetis; Michael |
| 20 | - | comic story | 20 | script: Gerry Duggan, Brian Posehn; pencils: Mike Hawthorne; inks: Mike Hawthorne; colors: Val Staples; letters: Joe Sabino | Deadpool; Benjamin Franklin (ghost); Emily Preston (ghost); Michael (mad necromancer S.H.I.E.L.D. agent, spirit); Spider-Man [Otto Octavius]; Batroc; Daniel Gump (introduction, dies); Trapster; Taskmaster; Chance; Lady Stilt Man |
| 21 | - | cover reprint (on interior page) | 1 | pencils: David Nakayama; inks: David Nakayama; colors: David Nakayama | Deadpool [Wade Wilson] |
| 22 | Character profile, credits & indicia | credits, title page | 1 | pencils: Irene Lee; inks: Irene Lee; colors: Irene Lee; letters: Joe Sabino | |
| 23 | Spideypool | comic story | 30 | script: Chris Hastings; pencils: Jacopo Camagni; inks: Jacopo Camagni; colors: Matt Milla; letters: Joe Sabino | Deadpool; Spider-Man; Chameleon |
| 24 | Behind the Scenes | text article | 2 | pencils: Ed McGuinness | Deadpool; Peter Parker; Blind Al; Weasel |
| 25 | Deadpool #11 Behind the Scenes | text article | 3 | pencils: Pete Woods, John Romita; inks: John Romita | Deadpool; Aunt May; Anna Watson; Weasel; Blind Al |