| 0 | - | cover | 1 | pencils: Ed McGuinness; inks: Mark Morales; colors: Marte Gracia | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Ed McGuinness; inks: Mark Morales; colors: Marte Gracia | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 2 | Isn't It Bromantic? Part One | comic story | 20 | script: Joe Kelly; pencils: Ed McGuinness; inks: Mark Morales; colors: Jason Keith; letters: Joe Sabino, Virtual Calligraphy; editing: Jordan D. White, Nick Lowe, Devin Lewis | Spider-Man [Peter Parker]; Deadpool; Mindless Ones; Hydro-Man; Anna Maria Marconi; Man-Thing; Frankenstein's Monster |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Will Sliney; inks: Will Sliney; colors: Frank Martin | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 4 | - | cover reprint (on interior page) | 1 | pencils: Ed McGuinness; inks: Ed McGuinness, Mark Morales; colors: Marte Gracia | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Spider-Man [Miles Morales] |
| 5 | Isn't It Bromantic?, Part Two | comic story | 20 | script: Joe Kelly; pencils: Ed McGuinness; inks: Mark Morales; colors: Jason Keith; letters: Joe Sabino | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Spider-Man [Miles Morales]; Anna Maria Marconi; Shiklah; Mysterio [Quentin Beck]; Patient Zero |
| 6 | - | cover reprint (on interior page) | 1 | pencils: John Tyler Christopher; inks: John Tyler Christopher; colors: John Tyler Christopher | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 7 | - | cover reprint (on interior page) | 1 | pencils: Ed McGuinness; inks: Ed McGuinness; colors: Jason Keith | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Terror [Shreck]; Solo [James Bourne]; Foolkiller [Kurt Gerhardt]; Masacre; Slapstick [Steve Harmon] |
| 8 | Isn't It Bromantic?, Part Three | comic story | 20 | script: Joe Kelly; pencils: Ed McGuinness; inks: Mark Morales; colors: Jason Keith; letters: Joe Sabino | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Spider-Man [Hobie Brown]; Anna Maria Marconi; Ellie Camacho; Mysterio [Quentin Beck]; Terror [Shreck]; Solo [James Bourne]; Foolkiller [Kurt Gerhardt]; Masacre; Slapstick [Steve Harmon]; Styx [Jacob Eichorn]; Stone [Gerald Stone]; Patient Zero |
| 9 | - | cover reprint (on interior page) | 1 | pencils: Ed McGuinness; inks: Ed McGuinness; colors: Jason Keith | Deadpool [Wade Wilson]; Spider-Man [Peter Parker]; Thor [Jane Foster]; Jenny |
| 10 | Isn't It Bromantic?, Part Four | comic story | 20 | script: Joe Kelly; pencils: Ed McGuinness; inks: Mark Morales; colors: Jason Keith; letters: Joe Sabino | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Thor [Jane Foster]; Shiklah; Ana Maria Marconi; Jenny |
| 11 | - | cover reprint (on interior page) | 1 | pencils: Ed McGuinness; inks: Ed McGuinness; colors: Jason Keith | Deadpool [Wade Wilson]; Spider-Man [Peter Parker] |
| 12 | Isn't It Bromantic?, Part Five | comic story | 20 | script: Joe Kelly; pencils: Ed McGuinness; inks: Mark Morales; colors: Jason Keith; letters: Joe Sabino | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Shiklah; Anna Maria Marconi; Mysterio [Quentin Beck]; Mephisto; Patient Zero |
| 13 | - | cover reprint (on interior page) | 1 | pencils: Ed McGuinness; inks: Mark Morales; colors: Jason Keith | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 14 | Isn't It Bromantic? [Part Six] | comic story | 20 | script: Joe Kelly; pencils: Ed McGuinness; inks: Mark Morales, Livesay; colors: Jason Keith; letters: Joe Sabino | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Anna Maria Marconi; Patient Zero |
| 15 | Paid & Full | cover reprint (on interior page) | 0.5 | pencils: Dave Johnson; inks: Dave Johnson; colors: Dave Johnson | Deadpool; Spider-Man [Peter Parker] |
| 16 | - | cover reprint (on interior page) | 0.5 | pencils: Alex Kropinak; inks: Alex Kropinak; colors: Alex Kropinak | Spider-Man; Deadpool |
| 17 | - | cover reprint (on interior page) | 0.5 | pencils: Rob Liefeld; inks: Rob Liefeld; colors: Chris Sotomayor | Deadpool; Spider-Man |
| 18 | - | cover reprint (on interior page) | 0.5 | pencils: Mike Del Mundo; inks: Mike Del Mundo; colors: Mike Del Mundo | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 19 | - | cover reprint (on interior page) | 0.5 | pencils: David Marquez; inks: David Marquez; colors: Marte Gracia | Deadpool [Wade Wilson]; Spider-Man [Peter Parker] |
| 20 | - | cover reprint (on interior page) | 0.5 | pencils: Ed McGuinness; inks: Ed McGuinness; colors: Andrew Crossley; letters: Ed McGuinness | Deadpool [Wade Wilson] |
| 21 | - | cover reprint (on interior page) | 0.25 | pencils: Cliff Chiang; inks: Cliff Chiang; colors: Cliff Chiang | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Spider-Man [Miles Morales] |
| 22 | - | cover reprint (on interior page) | 0.25 | pencils: Rob Liefeld; inks: Rob Liefeld; colors: Rob Liefeld | Deadpool [Wade Wilson] |
| 23 | - | cover reprint (on interior page) | 0.5 | pencils: Todd Nauck; inks: Todd Nauck; colors: Rachelle Rosenberg | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |