| 0 | - | cover | 1 | pencils: Will Robson; inks: Will Robson; colors: Richard Isanove | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Slapstick [Steve Harmon] |
| 1 | No More Jokes | cover reprint (on interior page) | 1 | pencils: Will Robson; inks: Will Robson; colors: Richard Isanove | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 2 | - | credits, title page | 1 | pencils: Ed McGuinness; inks: Ed McGuinness; colors: Jason Keith | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 3 | No Laughing Matter | comic story | 20 | script: Joshua Corin; pencils: Will Robson; inks: Will Robson; colors: Jordan Boyd; letters: Joe Sabino | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Slapstick [Steve Harmon]; Valeria Colon; El Tenor [Ferraro Colon] |
| 4 | - | cover reprint (on interior page) | 1 | pencils: Will Robson; inks: Will Robson; colors: Richard Isanove | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Slapstick [Steve Harmon] |
| 5 | - | credits, title page | 1 | pencils: Ed McGuinness; inks: Ed McGuinness; colors: Jason Keith | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 6 | No Laughing Matter: Part Two | comic story | 20 | script: Joshua Corin; pencils: Will Robson; inks: Scott Hanna; colors: Jordan Boyd; letters: Joe Sabino | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Slapstick [Steve Harmon]; El Tenor [Ferraro Colon]; Valeria Colon; El Toro Negro [Sergio Torres]; Alejandro |
| 7 | - | cover reprint (on interior page) | 1 | pencils: Will Robson; inks: Will Robson; colors: Frank D'Armata | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Arcade |
| 8 | - | credits, title page | 1 | pencils: Ed McGuinness; inks: Ed McGuinness; colors: Jason Keith | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 9 | One Night in Madripoor Makes Spider-Man Humble | comic story | 20 | script: Elliott Kalan; pencils: Todd Nauck; inks: Todd Nauck; colors: Rachelle Rosenberg; letters: Joe Sabino | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; The Stinger; Nathan Skreemie; Thornton Blackball; Seymour Crippen |
| 10 | - | cover reprint (on interior page) | 1 | pencils: Will Robson; inks: Will Robson; colors: Frank D'Armata | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Arcade |
| 11 | - | credits, title page | 1 | pencils: Ed McGuinness; inks: Ed McGuinness; colors: Jason Keith | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 12 | It's a Murder, Murder, Murder, Murder World | comic story | 20 | script: Elliott Kalan; pencils: Todd Nauck; inks: Todd Nauck; colors: Rachelle Rosenberg; letters: Joe Sabino | Spider-Man [Peter Parker]; Deadpool [Wade Wilson]; Arcade; Cyclops [Scott Summers]; Miss Locke the Second; Nathan Skreemie; Thornton Blackball; Seymour Crippen |
| 13 | Original Art | illustration | 19 | pencils: Will Robson, Todd Nauck; inks: Will Robson | Spider-Man [Peter Parker]; Deadpool [Wade Wilson] |
| 14 | - | cover reprint (on interior page) | 1 | pencils: Ed McGuinness; inks: Ed McGuinness; colors: Edgar Delgado | Itsy Bitsy (as Venom) |