| 0 | Mad - Buy It...or Leave It | cover | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | Alfred E. Neuman |
| 1 | Why Not Have the Next Issue Sent Directly to Your Home? | promo (ad from the publisher) | 0.5 | pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 2 | Schmoe | comic story | 6 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | Peter Boyle [as Schmoe Curran]; Susan Sarandon [as Melistless Compost]; Patrick McDermott [as Hank]; Dennis Patrick [as Bull Compost]; K. Callan [as Mrs. Curran]; Audrey Caire [as Mrs. Compost] |
| 3 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 4 | The Mad Non-Smoker's Hate Book | comic story | 4 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |
| 5 | New Movie Monsters From the Medical World | comic story | 3 | script: E. Nelson Bridwell; pencils: Jack Rickard; inks: Jack Rickard | |
| 6 | The Air Show | comic story | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | Major Hawks; Private Doves |
| 7 | The Lighter Side of Sound Equipment | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 8 | One Afternoon at the Beach | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 9 | Make Love - - Not War | photo story | 2 | script: Max Brandel | |
| 10 | A Collection of Mad X Ray-vings | cartoon | 2 | script: Don Edwing; pencils: Bob Clarke; inks: Bob Clarke | |
| 11 | Spy Vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 12 | The F.I.B. | comic story | 6 | script: Dick DeBartolo; pencils: Angelo Torres; inks: Angelo Torres | Efrem Zimbalist Jr. [as Lucas Oilyskin]; Philip Abbott [as Authority Word]; William Reynolds [as Tame Coldly] |
| 13 | Modern Art | photo story | 1 | script: Max Brandel; pencils: Irving Schild; inks: Irving Schild | |
| 14 | TV... as Viewed by the Animal World | comic story | 2 | script: Paul Peter Porges; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 15 | A Mad Peek Behind the Scenes at a Recording Studio | comic story | 2 | script: Chauncy Earle Doud; pencils: Jack Davis; inks: Jack Davis | |
| 16 | One Hot Summer Morning | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 17 | Incredible Occult Magazine | comic story | 7 | script: Frank Jacobs; pencils: George Woodbridge; inks: George Woodbridge | |
| 18 | The American Tourists in a Tokyo Restaurant | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 19 | What Deadly Missions Are More and More Servicemen Voluntarily Going on? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 20 | The Morning Delivery | photo story | 1 | script: Max Brandel; pencils: Irving Schild; inks: Irving Schild; colors: Irving Schild | |